N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamide

Name	Eliglustat
Synonyms	GENZ99067 GENZ99067 Eliglustat GENZ 99067 GENZ-99067 Genz 99067 GENZ 99067 GENZ-112638 ELIGLUSTAT TARTRATE Eliglustat(Genz-99067) Eliglustat(GENZ 112638) N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1- pyrrolidinyl)-2-propanyl]octanamide
CAS	491833-29-5

Molecular Formula	C23H36N2O4
Molar Mass	404.54
Density	1.123±0.06 g/cm3(Predicted)
Melting Point	87-92°C
Boling Point	615.5±55.0 °C(Predicted)
Solubility	10 mM in DMSO
Appearance	Solid
Color	White to Off-White
pKa	13.45±0.20(Predicted)
Storage Condition	2-8°C
In vitro study	Eliglustat tartrate is an inhibitor of glucosylceramide synthetase, which catalyzes the formation of glucosylceramide from UDP-glucose and ceramide. Eliglustat tartrate is highly specific for the inhibition of this enzyme and has limited or even no inhibitory activity against a variety of other glycosidases. In addition, 10 μm of Eliglustat tartrate had no inhibitory effect on sucrase and maltase.
In vivo study	Preclinical studies in normal mice, rats, dogs, by intravenous and oral routes of administration (Eliglustat Tartrate), in the spleen, the content of glucose in kidney and liver was significantly decreased. In rodents, Eliglustat Tartrate is rapidly metabolized in vivo with an in vivo half-life of 15-45 minutes.

Last Update：2024-01-02 23:10:35

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CAS: 491833-29-5
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Mobile: 18021002903
QQ: 3008007409

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N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamide Request for Quotation